Together, these finding indicate that the toxic effects of DOX on the heart are strongly associated with iron overload and ferroptosis in mitochondria, indicating that targeting ferroptosis could serve as a promising therapeutic strategy for protecting the hearts of cancer patients from DOX-induced cardiomyopathy
DNA methylation is an important factor for ensuring both healthy sperm function and embryo development [46,57]
Gene expression levels were determined using the 2^ (-CT) method, where CT = Ct, target-control
Doxorubicine-congestive heart failure-increased big endothelin-1 plasma concentration: Reversal by amlodipine, losartan, and gastric pentadecapeptide BPC157 in rat and mouse
Evidence from alcohol-related and chemical HCC models suggests that alcohol may polarize macrophages toward a pro-tumorigenic M2-like phenotype
Glutathione is a strong natural antioxidant that is synthesized in the body